| Feb 21, 2022 | Karjakin | 1–0 | Kramnik | Levitov Chess 50k Tournament | Italian Game: Giuoco Piano | |
| Feb 21, 2022 | Karjakin | 1–0 | Svidler | Levitov Chess 50k Tournament | Sicilian Defense: Najdorf Variation | |
| Feb 21, 2022 | Karjakin | 0–1 | Shimanov | Levitov Chess 50k Tournament | Nimzo-Larsen Attack: Modern Variation | |
| Feb 21, 2022 | Karjakin | 0–1 | Grischuk | Levitov Chess 50k Tournament | Trompowsky Attack | |
| Feb 21, 2022 | Dubov | 1–0 | Karjakin | Levitov Chess 50k Tournament | Italian Game: Classical Variation, Greco Gambit, Traditional Line | |
| Feb 21, 2022 | Fedoseev | 1–0 | Karjakin | Levitov Chess 50k Tournament | Ruy Lopez: Berlin Defense | |
| Feb 21, 2022 | Gelfand | ½–½ | Karjakin | Levitov Chess 50k Tournament | Slav Defense: Quiet Variation | |
| Jan 30, 2022 | Karjakin | 1–0 | Vidit | Tata Steel Chess Masters 2022 | Four Knights Game: Scotch Variation Accepted | |
| Jan 29, 2022 | Shankland | 1–0 | Karjakin | Tata Steel Chess Masters 2022 | Nimzo-Indian Defense: Kmoch Variation | |
| Jan 28, 2022 | Mamedyarov | ½–½ | Karjakin | Tata Steel Chess Masters 2022 | Italian Game: Classical Variation, Greco Gambit | |
| Jan 26, 2022 | Karjakin | ½–½ | Carlsen | Tata Steel Chess Masters 2022 | Ruy Lopez: Berlin Defense, Rio Gambit Accepted | |
| Jan 25, 2022 | Praggnanandhaa R | 0–1 | Karjakin | Tata Steel Chess Masters 2022 | Queen's Pawn Game: London System | |
| Jan 23, 2022 | Karjakin | ½–½ | Rapport | Tata Steel Chess Masters 2022 | French Defense: Advance Variation, Paulsen Attack | |
| Jan 22, 2022 | Grandelius | ½–½ | Karjakin | Tata Steel Chess Masters 2022 | Petrov's Defense: Nimzowitsch Attack | |
| Jan 21, 2022 | Karjakin | 1–0 | Van Foreest | Tata Steel Chess Masters 2022 | Italian Game: Classical Variation, Giuoco Pianissimo, with d6 | |
| Jan 20, 2022 | Duda | ½–½ | Karjakin | Tata Steel Chess Masters 2022 | Queen's Gambit Accepted: Central Variation, Greco Variation | |
| Jan 18, 2022 | Karjakin | ½–½ | Giri | Tata Steel Chess Masters 2022 | Grünfeld Defense: Exchange Variation, Modern Exchange Variation | |
| Jan 17, 2022 | Esipenko | 1–0 | Karjakin | Tata Steel Chess Masters 2022 | Italian Game: Classical Variation, Giuoco Pianissimo, with h6 | |
| Jan 16, 2022 | Karjakin | ½–½ | Dubov | Tata Steel Chess Masters 2022 | Tarrasch Defense: Dubov Tarrasch | |
| Jan 15, 2022 | Caruana | ½–½ | Karjakin | Tata Steel Chess Masters 2022 | Indian Defense: Anti-Nimzo-Indian | |
| Dec 30, 2021 | Karjakin | 0–1 | Mamedyarov | Open | Four Knights Game: Scotch Variation Accepted | |
| Dec 30, 2021 | Karjakin | 1–0 | Moroni | Open | Modern Defense: Standard Line | |
| Dec 30, 2021 | Karjakin | 0–1 | Kobalia | Open | Nimzo-Larsen Attack: Modern Variation | |
| Dec 30, 2021 | Duda | 1–0 | Karjakin | Open | English Opening: Agincourt Defense, Wimpy System | |
| Dec 30, 2021 | Asadli | 0–1 | Karjakin | Open | Sicilian Defense: Closed | |
| Dec 30, 2021 | Donchenko | 1–0 | Karjakin | FIDE World Blitz Championship | English Opening: Neo-Catalan | |
| Dec 29, 2021 | Karjakin | 1–0 | Bellahcene | Open | Sicilian Defense: Four Knights Variation | |
| Dec 29, 2021 | Karjakin | 0–1 | Postny | Open | Ruy Lopez: Closed | |
| Dec 29, 2021 | Karjakin | 0–1 | Chigaev | Open | French Defense: Winawer Variation, Advance Variation | |
| Dec 29, 2021 | Karjakin | ½–½ | Riazantsev | Open | Sicilian Defense: Moscow Variation, Main Line | |
| Dec 29, 2021 | Karjakin | ½–½ | Caruana | Open | Ruy Lopez: Morphy Defense, Modern Steinitz Defense | |
| Dec 29, 2021 | Santos Latasa | 1–0 | Karjakin | Open | English Opening: Symmetrical Variation, Botvinnik System Reversed, with Nf3 | |
| Dec 29, 2021 | Costachi | 0–1 | Karjakin | Open | Queen's Indian Defense: Fianchetto Variation, Nimzowitsch Variation | |
| Dec 29, 2021 | Janik | 0–1 | Karjakin | Open | Sicilian Defense: Moscow Variation | |
| Dec 29, 2021 | Saric | 0–1 | Karjakin | Open | Sicilian Defense: Najdorf Variation | |
| Dec 29, 2021 | Ter-Sahakyan | 0–1 | Karjakin | Open | Sicilian Defense: Najdorf Variation | |
| Dec 29, 2021 | Socko | 0–1 | Karjakin | Open | Queen's Indian Defense: Miles Variation | |
| Dec 28, 2021 | Karjakin | 1–0 | Amin | Open | Italian Game: Classical Variation, Giuoco Pianissimo | |
| Dec 28, 2021 | Karjakin | 1–0 | Firouzja | Open | King's Indian Defense: Exchange Variation | |
| Dec 28, 2021 | Anton Guijarro | 0–1 | Karjakin | Open | Queen's Pawn Game: Colle System | |
| Dec 28, 2021 | Fedoseev | ½–½ | Karjakin | Open | Catalan Opening: Open Defense, Classical Line | |
| Dec 27, 2021 | Karjakin | 1–0 | Gabuzyan | Open | Sicilian Defense: Najdorf Variation | |
| Dec 27, 2021 | Karjakin | ½–½ | Mitrabha | Open | Caro-Kann Defense: Apocalypse Attack | |
| Dec 27, 2021 | Aditya | 0–1 | Karjakin | Open | Queen's Indian Defense: Fianchetto Variation, Nimzowitsch Variation | |
| Dec 27, 2021 | Ghaem Maghami | 0–1 | Karjakin | Open | Queen's Indian Defense: Kasparov-Petrosian Variation, Main Line | |
| Dec 26, 2021 | Karjakin | ½–½ | Christiansen | FIDE World Rapid Championship | King's Indian Attack: Double Fianchetto | |
| Dec 23, 2021 | Karjakin | 1–0 | Navara | Vugar Gashimov Memorial | Nimzo-Larsen Attack: Classical Variation | |
| Dec 23, 2021 | Karjakin | ½–½ | Caruana | Vugar Gashimov Memorial | Ruy Lopez: Marshall Attack, Modern Variation | |
| Dec 23, 2021 | Karjakin | 0–1 | Mamedov | Vugar Gashimov Memorial | Trompowsky Attack | |
| Dec 23, 2021 | Rapport | ½–½ | Karjakin | Vugar Gashimov Memorial | Ruy Lopez: Closed, Center Attack | |
| Dec 23, 2021 | Mamedyarov | 1–0 | Karjakin | Vugar Gashimov Memorial | Nimzo-Indian Defense: Classical Variation, Noa Variation | |
| Dec 23, 2021 | Anand | ½–½ | Karjakin | Vugar Gashimov Memorial | Alekhine Defense: Modern Variation, Larsen Variation | |
| Dec 23, 2021 | Asadli | ½–½ | Karjakin | Vugar Gashimov Memorial | Caro-Kann Defense: Advance Variation, Short Variation | |
| Dec 22, 2021 | Karjakin | 0–1 | Rapport | Vugar Gashimov Memorial | King's Indian Defense: Orthodox Variation, Glek Defense | |
| Dec 22, 2021 | Karjakin | 0–1 | Mamedyarov | Vugar Gashimov Memorial | Italian Game: Classical Variation, Giuoco Pianissimo, with h6 | |
| Dec 22, 2021 | Karjakin | ½–½ | Anand | Vugar Gashimov Memorial | Ruy Lopez: Berlin Defense | |
| Dec 22, 2021 | Karjakin | 0–1 | Asadli | Vugar Gashimov Memorial | Caro-Kann Defense: Advance Variation, Botvinnik-Carls Defense | |
| Dec 22, 2021 | Navara | 0–1 | Karjakin | Vugar Gashimov Memorial | Sicilian Defense: Moscow Variation | |
| Dec 22, 2021 | Caruana | ½–½ | Karjakin | Vugar Gashimov Memorial | King's Knight Opening: Konstantinopolsky | |
| Dec 22, 2021 | Mamedov | 1–0 | Karjakin | Vugar Gashimov Memorial | Caro-Kann Defense: Classical Variation | |
| Dec 21, 2021 | Karjakin | 1–0 | Asadli | Vugar Gashimov Memorial | Caro-Kann Defense: Advance Variation, Botvinnik-Carls Defense | |
| Dec 21, 2021 | Karjakin | 1–0 | Mamedov | Vugar Gashimov Memorial | Sicilian Defense: Lasker-Pelikan Variation | |
| Dec 21, 2021 | Asadli | ½–½ | Karjakin | Vugar Gashimov Memorial | Italian Game: Classical Variation, Greco Gambit, Traditional Line | |
| Dec 21, 2021 | Mamedov | ½–½ | Karjakin | Vugar Gashimov Memorial | Italian Game: Classical Variation, Greco Gambit, Moeller-Therkatz Attack | |
| Dec 20, 2021 | Karjakin | ½–½ | Anand | Vugar Gashimov Memorial | Ruy Lopez: Berlin Defense | |
| Dec 20, 2021 | Karjakin | ½–½ | Caruana | Vugar Gashimov Memorial | Ruy Lopez: Morphy Defense, Modern Steinitz Defense | |
| Dec 20, 2021 | Anand | 0–1 | Karjakin | Vugar Gashimov Memorial | Italian Game: Classical Variation, Giuoco Pianissimo | |
| Dec 20, 2021 | Caruana | ½–½ | Karjakin | Vugar Gashimov Memorial | English Opening: Four Knights System, Nimzowitsch Variation | |
| Dec 20, 2021 | Caruana | ½–½ | Karjakin | Vugar Gashimov Memorial | English Opening: King's English Variation, Four Knights Variation, Flexible Line | |
| Dec 19, 2021 | Karjakin | 1–0 | Navara | Vugar Gashimov Memorial | Ruy Lopez: Berlin Defense | |
| Dec 19, 2021 | Karjakin | 1–0 | Mamedyarov | 7th Gashimov Memorial | Italian Game: Classical Variation, Giuoco Pianissimo, with h6 | |
| Dec 19, 2021 | Navara | 1–0 | Karjakin | 7th Gashimov Memorial | Zukertort Opening | |
| Dec 19, 2021 | Navara | 0–1 | Karjakin | 7th Gashimov Memorial | King's Indian Attack: Double Fianchetto | |
| Dec 19, 2021 | Mamedyarov | 0–1 | Karjakin | Vugar Gashimov Memorial | Italian Game: Classical Variation, Greco Gambit, Traditional Line | |
| Dec 18, 2021 | Karjakin | 0–1 | Rapport | Vugar Gashimov Memorial | French Defense: Winawer Variation, Advance Variation | |
| Dec 18, 2021 | Rapport | * | Karjakin | Vugar Gashimov Memorial | Sicilian Defense: Moscow Variation | |
| Oct 12, 2021 | Vidit | ½–½ | Karjakin | Chess Super League 2021 | Catalan Opening: Open Defense, Classical Line | |
| Oct 11, 2021 | Karjakin | 1–0 | Sasikiran | Chess Super League 2021 | Sicilian Defense: Najdorf Variation, Adams Attack | |
| Sep 17, 2021 | Karjakin | ½–½ | Tari | Norway Chess | Indian Defense: Anti-Nimzo-Indian | |
| Sep 17, 2021 | Karjakin | 1–0 | Tari | Norway Chess | Nimzo-Larsen Attack: Classical Variation | |
| Sep 16, 2021 | Carlsen | 1–0 | Karjakin | Norway Chess | Ruy Lopez: Berlin Defense | |
| Sep 15, 2021 | Karjakin | 0–1 | Firouzja | Norway Chess | Sicilian Defense: Najdorf Variation, Adams Attack | |
| Sep 14, 2021 | Rapport | 1–0 | Karjakin | Norway Chess | Nimzo-Indian Defense: Three Knights Variation | |
| Sep 13, 2021 | Karjakin | ½–½ | Nepomniachtchi | Norway Chess | Catalan Opening: Open Defense, Classical Line | |
| Sep 13, 2021 | Karjakin | 1–0 | Nepomniachtchi | Norway Chess | Bishop's Opening: Berlin Defense | |
| Sep 12, 2021 | Karjakin | 1–0 | Carlsen | Norway Chess | Sicilian Defense: Lasker-Pelikan Variation | |
| Sep 10, 2021 | Tari | ½–½ | Karjakin | Norway Chess | Ruy Lopez: Berlin Defense, Rio Gambit Accepted | |
| Sep 10, 2021 | Tari | 0–1 | Karjakin | Norway Chess | Ruy Lopez: Berlin Defense | |
| Sep 9, 2021 | Firouzja | ½–½ | Karjakin | Norway Chess | Italian Game: Classical Variation, Giuoco Pianissimo | |
| Sep 9, 2021 | Firouzja | 0–1 | Karjakin | Norway Chess | Nimzo-Larsen Attack: Modern Variation | |
| Sep 8, 2021 | Karjakin | ½–½ | Rapport | Norway Chess | Sicilian Defense: Taimanov Variation, Bastrikov Variation, English Attack | |
| Sep 7, 2021 | Nepomniachtchi | * | Karjakin | Norway Chess | ? | |
| Aug 16, 2021 | Karjakin | 1–0 | Chigaev | Region Group Cup | King's Indian Defense: Semi-Classical Variation, Queenside Storm Line | |
| Aug 16, 2021 | Karjakin | 0–1 | Esipenko | Region Group Cup | Indian Defense: London System | |
| Aug 16, 2021 | Karjakin | ½–½ | Karpov | Region Group Cup | Indian Defense: London System | |
| Aug 16, 2021 | Karjakin | 0–1 | Predke | Region Group Cup | Queen's Pawn Game: London System | |
| Aug 16, 2021 | Karjakin | 0–1 | Alekseenko | Region Group Cup | Queen's Pawn Game: Accelerated London System | |
| Aug 16, 2021 | Karjakin | 1–0 | Najer | Region Group Cup | Indian Defense: London System | |
| Aug 16, 2021 | Karjakin | ½–½ | Potkin | Region Group Cup | Indian Defense | |
| Aug 16, 2021 | Chigaev | 1–0 | Karjakin | Region Group Cup | Caro-Kann Defense: Advance Variation, Tal Variation | |